You can create new items by combining existing ones in Little Alchemy. To get started, you will need four different things. You can use them to make dinosaurs, spaceships, and unicorns with them. You need to give some thought to why you want to combine certain things.
Move the items you want to combine from the left menu to the middle screen using the drag and drop method. Simply dragging one object on top of another will combine the two. Utilize the encyclopedia in order to keep track of your progress and gain more information about the objects you have discovered.
The beginning is always the hardest part for alchemists. To your good fortune, there is a "clean-up" button located in the top left corner of the screen, which will clear your canvas. The search function that is located in the top right corner of the screen can also be very helpful if you are having trouble keeping track of your work.